微生物与宿主健康研究团队是由国家重点人才项目入选者（青年）、山东省“泰山学者”特聘教授、浙江省特聘专家、欧盟（荷兰）Rubicon学者、山东省高等学校优秀青年创新团队带头人张兴林教授2018年全职引进公司后组建。团队主要从事微生物与宿主健康相关的研究工作。（1）针对引发宿主重要疾病的病原微生物，开展其流行病学调查和分离鉴定工作，利用国际前沿的微生物学方法Tn-seq，高通量筛选、鉴定病原微生物致病相关的毒力基因，研究病原微生物的致病机制。（2）完善功能基因组学研究平台，在功能基因组层面对病原微生物进行系统的基因功能研究，为疾病的防控提供重要理论基础；（3）搭建一种病原微生物通用，可控、安全、有效的新型疫苗研究平台，开展疫苗设计、安全性和保护性等相关实验室研究工作，为疾病防控提供有效的技术手段和科学支撑，并为突发传染病的紧急预防控制提供技术贮备；（4）开发微生物技术，重点进行细菌素的筛选、鉴定等研究工作，实现相关技术与产品的转化。

目前，团队承担国家和省部级科研项目30余项，包括山东省自然基金重大基础研究项目、山东省高等学校青年创新团队项目、山东省“泰山学者工程”、国家重点人才项目（青年），国家“十三五”重点研发计划子课题等科研项目。在Nature Natotechnol、PLoS Genet、Environ Microbiol、J Infect Dis、BMC Genomic、Nature Microbiol等国际知名期刊上发表论文，研究成果多次被Nature和Annual Review of Microbiology等顶级期刊引用。

团队代表性科研项目

团队代表性学术论文

1.      Liu. X,Shu. Q,Chen. Q,Pang. X,Wu.Y,Zhou. W,Wu. Y,Niu. J†,Zhang. X†,Antibacterial Efficacy and Mechanism of Mannosylerythritol Lipids-A on Listeria monocytogenes, Molecules.2020 Oct 21

2.      Peikun Wang, jianrui Niu, Cong Xue, Zhaoqing Han, Amro Abdelazez, Xinglin Zhang*, Two novel recombinant avian leukosis virus isolates from Luxi gamecock chickens, Archives of Virology, 2020.12, 165:(12):2877-2881

3.      Wanyi Zhou, Jingjin Hu, Xinglin Zhang†, Qihe Chen†, Application of bamboo leaves extract to Chinese yellow rice wine brewing for ethyl carbamate regulation and its mitigation mechanism, Food Chemistry, 2020, 319:126554.

4.      Peikun Wang^#; Lulu Lin^#; Mengya Shia; Haijuan Li; Zhanming Gu; Min Li; Yanli Gao; Huang Teng; Meilan Mo; Tianchao Wei; Ping Wei*; Vertical transmission of ALV from ALV-J positive parents caused severe immunosuppression and significantly reduced marek’s disease vaccine efficacy in three-yellow chickens,Veterinary Microbiology, 2020,244:108683.

5.      Peikun Wang; Min Li; Haijuan Li; Lulu Lin; Mengya Shi; Zhanming Gu, Yanli Gao; Teng Huang,Meilan Mo; Tianchao Wei; Ping Wei*; Full-length cDNA sequence analysis of 85 avian leukosis virus subgroup J strains isolated from chickens in China during the years 1988–2018: coexistence of 2 extremely different clusters that are highly dependent upon either the host genetic background or the geographic location, Poultry Science, 2020,99(7): 3469-3480.

6.       Zhaoqing Han#, Aoyun Li#, Lulu Pei, Kun Li, Taihua Jin, Fukuan Li, Zhennan Wang, Shenjin Lv*, Yongzhu Li*; Milk Replacer Supplementation Ameliorates Growth Performance and Rumen Microbiota of Early-Weaning Yimeng Black Goats, Frontiers in Veterinary Science, 2020, 7: 572064.

7.       Zhaoqing Han#, Kun Li#, Houqiang Luo, Muhammad Shahzad, Khalid Mehmood; Characterization of the Complete Mitochondrial Genome of Fischoederius elongatus Derived from Cows in Shanghai, China, BioMed Research International, 2020, 2020: 1-6.

8.      Zhang L, Zhao J, Zhai Z, et al. Cellular microRNA, miR-1343-5p, modulates IFN-I responses to facilitate feline panleukopenia virus replication by directly targeting IRAK1 gene.Veterinary Microbiology, 2020, 245:108691

9.      Lumin Yu#*; Wenchang Li#; Zhichao Liu; JiangliYu; Wenhui Wang; Fei Shang*; Ting Xue*; Role of McbR in the regulation of antibiotic susceptibility in avian pathogenic Escherichia coli, Poultry Science, 2020, 99(12):6390-6401.

10.   Lumin Yu#; Hui Wang#; Xiangan Han; Wenchang Li; Mei Xue; Kezong Qi; Xiaolin Chen; Jingtian Ni; Ruining Deng; Fei Shang*; Ting Xue*; The two-component system, BasSR, is involved in the regulation of biofilm and virulence in avian pathogenic Escherichia coli, Avian Pathology, 2020, 49(6):532-546.

11.   Lumin Yu; Wenchang Li; Qian Li; Xiaolin Chen; Jingtian Ni; Fei Shang*; Ting Xue*; Role of LsrR in the regulation of antibiotic sensitivity in avian pathogenic Escherichia coli, Poultry Science, 2020, 99(7):3675-3687.

12.   Cao Xiaoyan, Che Zhiqun, Zhou Bo, Guan Baohu, Chen Guiguang, Zeng wei, Zhiqun Liang*. Investigations in ultrasound-assisted anticoagulant production by marine Bacillus subtilis ZHX [J]. Ultrasonics Sonochemistry, 2020, 64(104994)

13.   Xiaohong Xu^#, Cong Xue^#, Xinxin Liu, Junjiao Li, Yidong Fei, Zhe Liu, Jiaqi Mu, Yuhai Bi, Jing Qian, Renfu Yin^*, Zhuang Ding^*，A novel recombinant attenuated Newcastle disease virus expressing H9 subtype hemagglutinin protected chickens from challenge by genotype VII virulent Newcastle disease virus and H9N2 avian influenza virus, Veterinary Microbiology, 2019, 228: 173-180

14.   B. Peng†, X. Zhang†,  D.G.A.L. Aarts and R. Dullens. 2018. Superparamagnetic colloidal nickel nanocrystal clusters with antibacterial activity and bacteria binding ability. Nat Nanotechnol 13, pages478–482 (2018)

15.   X. Zhang, V. de Maat, A.M. Guzmán, T.K. Prajsnar, J.R. Bayjanov, M. de Been, M. R.C. Rogers, M. J.M. Bonten, S. Mesnage, R. J.L. Willems, W. van Schaik. 2017. RNA-seq and Tn-seq reveal fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum. BMC Genomics 18 (1), 893.